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KMID : 0361020000430070731
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 7 p.731 ~ p.736
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Expression of Glucocorticoid Receptor in Nasal Polyps and Nasal Mucosa
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Kang Jun-Myung
Cho Jin-Hee
Won Yu-Sung
Kim Sung-Shik
Chang Han-Sung
Yoon He-Ro
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Abstract
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Background and Objectives : Glucocorticoids are currently the most potent medication available for the
treatment of nasal polyposis and allergic rhinitis, but exact mechanisms and cellular targets in the nasal
mucosa are uncertain. Multifactorial effects of glucocorticoid are initiated by their binding to specific
cytoplasmic glucocorticoid receptor (GR). We performed this study to investigate the localization and
distribution of human GR and GR β isoform in nasal mucosa and to examine the influence of allergy and
eosinophilic infiltration on GR and GR β isoform expression in nasal polyps.
Materials and Methods : Nasal polyps (NP), middle turbinate mucosa (MT) and inferior turbinate (IT)
mucosa were taken from 40 patients with chronic sinusitis and nasal polyps. We examined to have
concomitant allergic rhinitis. Specimens were stained to quantify eosinophils and immunohistochemically
stained to quantify GR and GR β isoform in the unit area of tissues.
Results : Immunostainning of GR and GB β isoform was predominantly localized in epithelial cell and infiltration inflammatory cell in subepithelial layer, with lesser amounts in the endothelial cells and in the cells surrounding
glands. Immunostaining of GR was mostly co-expressed with GR β isoform. No correlation was found between
GR and GR β isoform expression in subepithelial layer and the intensity of eosinophilic inflammation and
allergy in NP.There was no significant differences in GR and GR β isoform expression between NP,MT,and IT.
Conclusion : Epithelial cells may be an important site of action for intranasal steroids, and the increased
number of eosinophils infiltrating the mucosa and allergy did not amplify the number of immunostaining of
GR and GR β isoform.
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KEYWORD
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Glucocorticoid receptors, Nasal polyps, Allergic rhinitis
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